Manuel Neuer is absent from the squad and Ron-Robert Zieler is likely to get the nod over Roman Weidenfellerbetween the sticks.
Further forward, Max Kruse should start in a lone striking role, with Patrick Herrmann, Mesut Ozil and Andre Schurrlepossibly starting in a three-pronged attacking midfield.
Jerome Boateng and Mats Hummels are both in the squad, but they might be rested as Antonio Rudiger and Shkodran Mustafi could start in central defence.
Gibraltar, meanwhile, are likely to start with a three-man central defence of Jack Sargeant, Roy Chipolina and Ryan Casciaro. Another Casciaro, Kyle, could lead the line for the hosts.
Only Georgia scored fewer than Germany against Gibraltar in the first half of qualifying and Low's men will want to make a statement after the surprise late defeat to the States.