Despite both countries sitting pretty on 11 points, it is Belgium who top the table by virtue of goal difference.
A win for Wales would take them one step closer to the 2016 European Championships in France, a remarkable achievement given they have not qualified for the finals of a major tournament since the World Cup in 1958.
Chris Coleman has already lost James Collins and Ben Davies to injury, while Crystal Palace midfielder Jonny Williams and Fulham's George Williams were unavailable for selection.
Despite niggling injuries to a number of key squad members, Wales expect James Chester and Aaron Ramsey to be fit for Friday's match. Paul Dummett has withdrawn from the squad due to a hamstring injury.
Belgium will be without Marouane Fellaini, who has had to pull out of the match with a pelvic injury. The midfielder, who is Belgium's top scorer in qualifying with five goals, limped out of training on Wednesday and had to undergo an MRI scan.
Belgium go into the game off the back of a remarkable 4-3 friendly win over France in Paris. Despite leading 3-0 and 4-1, Belgium squandered their advantage by conceding two goals in the last two minutes, but managed to hold on for the win.
Gareth Bale is set to make his 50th international appearance for Wales against Belgium.
This is Wales's 100th UEFA European Championship game. Their record in the previous 99 reads W38 D20 L41.